Thank you for holding. And welcome to the Titan Pharmaceuticals First Quarter 2019 Financial Results Conference Call. At this time, all participants are in a listen-only mode. There will be a question-and-answer session following today's remarks. Please be advised that this call is being taped at the company’s request, and will be archived on the company’s website starting later today. At this time, I’d like to turn the call over to Sunil Bhonsle, President and CEO of Titan Pharmaceuticals. Please go ahead.

Thank you, Keith, and thank you all for joining us. Welcome to the Titan Pharmaceuticals call to review financial and operational results for the first quarter ended March 31, 2019, and we’ll provide an update on our business. Now before we begin, I wanted to inform you that we filed our quarterly report on Form 10-Q with the SEC and the press release issued earlier today provides a summary of the results and can be found on our website at titanpharm.com. Joining me on the call today from Titan are Dr. Marc Rubin, our Executive Chairman; Dr. Kate DeVarney, our Executive Vice President and Chief Scientific Officer; Dane Hallberg, our Executive Vice President and Chief Commercial Officer; and Brian Crowley, Vice President of Finance. Before we go into the details of the financial results and provide an update on the company, Jennifer Kiernan will review the required cautions regarding forward-looking statements. Jennifer?

Thank you, Sunil. I want to remind everyone that certain matters that will be discussed today other than historical information may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, any statements relating to our product commercialization and development programs and any other statements that are not historical facts. Such statements involve risks and uncertainties that could negatively affect our business, operating results, financial conditions and stock price. Factors that could cause actual results to differ materially from management’s current expectations, include those risks and uncertainties relating to the commercialization of Probuphine; the regulatory approval process; the development, testing, production and marketing of our drug candidates; patent and intellectual property matters; and strategic agreements and relationships. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law. And now back to you, Sunil.

Thank you, Jennifer. As always, we will start the call with an overview from our Executive Chairman, Dr. Marc Rubin followed by commercial updates from Dane Hallberg and then Medical Affairs Regulatory and Product Development updates from Dr. Kate DeVarney. Brian Crowley will then summarize the financial results. And I will close with a brief recap before opening the call for your questions. So we’ll go ahead, get started. Marc?

Thank you, Sunil, and hello, everyone. Thank you for joining us this afternoon. As you all know we provided an update quite recently on April 2 together with the full year and fourth quarter 2018 results. And since only a few weeks have passed since the last call I will briefly focus on the most recent activities and accomplishments. And that's not to say we have been busy. Indeed Titan reported several key developments since the last conference call and I'd like to highlight three. First, we expanded our specialty pharmacy network through partnerships with AllianceRx Walgreens Prime which recently placed an order to stock specialty pharmacies in five key geographies. And more recently with Accredo which is a specialty pharmacy unit of Express Scripts. Secondly, in April we commenced transition of the Probuphine hub to AppianRx and this is an important change for us. It's one that's going to significantly improve our ability to provide key patient and healthcare provider services for accessing treatment with Probuphine. Finally, we announced that the European medicines agency adopted a positive opinion recommending a Sixmo which is the name in Europe for a market authorization. This is a major milestone towards advancing the global footprint of Probuphine. In addition, our sales, marketing and medical affairs teams participated in the annual meeting of the American Society for Addiction Medicine in Orlando, and as you may know this is the preeminent U.S. conference on addiction medicine. We were very impressed and very pleased with the continuous stream of participants that came to our booth to learn more about Probuphine. Our presence at the meeting actually generated a great deal of new interest in the product and in fact there was more demand for the Probuphine REMS training session which we conducted during the conference than we were able to actually accommodate. And I’m going to let Dane and Kate elaborate on all of these activities and more starting with the commercial area. And with that I will turn it over to you, Dane.

Thank you very much, Marc. Hello everybody and good to speak with you once again. Let me start with a very important accomplishment. As discussed in our last call we selected AppianRx as the new hub for Probuphine and during the month of April integrated AppianRx into the Probuphine ordering process. The key to making Probuphine available to eligible patients is the ability to make the product ordering and treatment process a smooth one for prescribers and patients. AppianRx will enable more efficient interaction between physician, payers, specialty pharmacies by managing elements such as benefits verification prior authorization and appeals, and copay and patient assistance programs. We have been working closely with AppianRx to develop this efficient new hub and the initial feedback from the users is very encouraging, as we have seen a remarkable increase in efficiency and reduction in paperwork errors and omissions. We are also pleased to engage AllianceRx Walgreens, specialty pharmacy to support Probuphine supply chain process AllianceRx has been adding Probuphine to their system, facilitating patient access to treatment by streamlining the product ordering fulfillment process. In line with our strategy we have continued to pursue opportunities to expand our network with additional well-established nationally recognized specialty pharmacy and recently announced a product purchase and supply agreement with Accredo specialty pharmacy, a subsidiary of Express Scripts. Accredo is one of the largest U.S. specialty pharmacies with an award-winning advanced opioid management program. So we are pleased to partner with Accredo through this, the second major specialty pharmacy distribution agreement signed since relaunching Probuphine in the U.S. We have built a strong commercial foundation. We continue to pursue opportunities to expand our specialty pharmacy network or pursuing greater market access amongst third-party payers. During the last few months we have also made important progress with Medicare and Medicaid programs and initiated the process with the Veterans Administration to establish a Federal supply schedule agreement. We have continued to increase awareness of Probuphine through various outreach and marketing initiatives which has increased the number of active prescribers from under 200 in Q4 of last year to nearly 300 and growing. Additionally, we recently attended a meeting hosted by the Academy of Managed Care Pharmacy, which uses an evidence-based approach to help patient’s access safe and cost effective medicines, and held meetings with several large national payers in effort to increase patient access to Probuphine for their members. We also attended the meeting hosted by the NAMCP, a nonprofit that offers resources to help purchasers, plans and providers make effective and informed decisions. And finally, we had a significant presence at the Rx Drug Abuse Heroin Summit which hosts an international discussion addressing the opioid crisis. We recently attended the American Society of Addiction Medicine or ASAM Annual Conference in Orlando, Florida where we conducted meetings with key stakeholders participated as an exhibitor held interviews with the news media and unveiled our newly launched brand campaign step into stability which has proven to resonate positively with key stakeholders. We plan on doing the same at upcoming conferences including the American Academy of Physician Assistants or AAPA and the American Academy of Nurse Practitioners or a AANP. Through our public relations program we have established relationships with a wide variety of media and earned coverage in several major news outlets. Dr. DeVarney and I were interviewed by Jerry Penacoli of News Channel, its Daytime Program and the interview aired in the Tampa Florida TV stations on April 25 and was syndicated to over 220 affiliates nationwide. Recently Dr. Michael Frost, an Addiction Medicine Clinical Expert participated in more than 20 interviews with radio and TV program host, which are aired in several regions already and help to increase awareness of medication assistance treatment for opioid use disorder and of course Probuphine. I will turn the call over to our Chief Scientific Officer Dr. Kate DeVarney who will discuss Titan’s progress on our medical affairs, regulatory, drug safety compliance functions as well as product development. Kate?

Thank you very much Dane, and hello everyone. First, our medical affairs and our drug safety compliance team continue to provide Probuphine training and certification to healthcare providers across the country. And as Dane mentioned, Probuphine debut an ASAM, which is our first major U.S. addiction medicine conference and it generated lots of interest from a variety of stakeholders including prescribers. And in addition to the Probuphine commercially exhibit that Dane described, the Medical Affairs team had a separate exhibit to provide one-on-one discussions with healthcare providers and others about scientific and medical questions including REMS training. We also took this opportunity to provide a REMS training in which we certified more than 30 healthcare providers. We continue to have regular training sessions and plan on providing REMS training and additional medical conferences this year including the upcoming AAPA and AAMP. Nurse petitioners are very important and integral part of the overall treatment paradigm for patient with opioid use disorder and we're focusing our efforts on training those with surgical experience. At the end of April we were pleased to announce that the European Medicines Agencies Committee for Medicinal Products for Human Use adopted a positive opinion that recommended granting marketing authorization for the Medicinal product Sixmo, which as Marc mentioned in the brands name for Probuphine in the European Union. When approved Sixmo would be indicated for substitution treatment for opioid dependence in clinically stable adult patients who require no more than 8 milligrams a day of sublingual Probuphine, and this is within a framework of medical social and psychological treatments. This positive opinion of Sixmo will now be transmitted to the European Commission which is expected to issue its decision for Sixmo for all 28 member states of the EU towards the end of June 2019. And we’re certainly looking forward to supporting Molteni as it prepares for Sixmo’s pending European commercial launch, while we continue to evaluate opportunities to commercialize the product and additional regions around the world. Now, in the US we are completing final preparations for starting our first phase we’re studying in Probuphine and this study will evaluate safety and pharmacokinetics of reimplantation into a previously used site on a patient’s inner, upper arm as well implantation into the abdomen. We expect to initiate this trial during third quarter of this year. A second Phase for trial assessing implant procedure safety is expected to begin before the end of 2019. And we're also participating in an Industry Consortium Study to evaluate QT prolongation and people treated various formulations of buprenorphine. As you may know last September we were awarded a grant by the National Institute for Drug Abuse, NIDA, to develop a subdermal implant using our proprietary ProNeura technology to administer a drug called nalmefene which is in opioid antagonist and this will be for the prevention of opiod relapse and over dose in patients with opioid use disorder who have undergone detoxification. The two-year grant award of approximately $8.7 million subject to the terms and conditions specified in the grant including our find matching obligations amount for approximately $1.3 million during the first year, this support and its efficient to fund the formulation development and non-clinical testing that is required to file the ING. We’ve make good progress to-date and are currently optimizing the n nalmefene implant formulation in nonclinical animal models. So far, we’re on track to file this IND as planned in the last half of 2020. We are also collaborating with the Walter Reed Army Institute of Research and the Southwest research institute to evaluate our ProNeura platform for malaria prophylaxis. We’re currently working on a novel implant formulations of compounds that are of interest to the Army which is if successful could be available to us for potential commercialization. And finally, we’re also seeking additional grant funding through other mechanisms to support further development of Probuphine as well as other new product opportunities. That concludes my remarks for today. And I really look forward to keeping you all updated on our progress over the next several months. And now, I’ll turn the call to Brian to discuss Titan's financial results. Brian?

Thank you, Kate. A summary of our financial results was provided in a press release today and details are available are Form 10-Q filed with the SEC. At this time, I’ll just highlight two key items. Please note that all the numbers I'm about to provide have been rounded and are therefore approximate and have been adjusted to reflect the January 2019 reverse split of our common stock. In the first quarter of 2019, we’ve recorded $0.9 million of revenues. This included $0.3 million from product sales, a 46% sequential increase over the prior quarter. $0.3 million related to the amortization of deferred revenue from the sale to Molteni of the European Intellectual property rights to Probuphine and $0.3 million grant revenues related to our nalmefene product development project. This compared with revenues of approximately $1.1 million in the same period in 2018, which were primarily related to the upfront payment from the sale of the European Intellectual Property rights for Probuphine to Molteni First quarter 2019 operating expenses consisting primarily of R&D and SG&A expenses and costs to good sold were $5.2 million compared with $3.5 million in the same quarter in 2018. The first quarter 2019 operating expense includes $1.7 million in sales and marketing related expenses that were not present in the comparable quarter of 2018. Our net loss attributable to common shareholders in the first quarter 2019 was $4.5 million or $0.34 per share compared with a net loss of $2.6 million or $0.74 per share in the same quarter of 2018. At March 31, 2019 we had cash and cash equivalents of $5.9 million, which we believe is sufficient to fund our planned operations through August 2019. Subsequent to the end of the first quarter we entered into an aftermarket sales agreement with alliance global partners for the sale of our common stock at market price. Now, I’ll pass the call back to Sunil. Sunil?

Thank you. That was a good summary of all of the activities and as I can very strongly say, it has been a very productive quarter and we’re very pleased with the team's progress which includes the execution of a patient support services agreement with AppianRx and the integration of the new hub into the Probuphine ordering process, addition of two large specialty pharmacies that will help improve the patient access to Probuphine all of which are key to our commercialization strategy for Probuphine. The focus during the last few months on healthcare providers who actively prescribe Probuphine is starting to bear fruit and training select new ones will have the right patient population is starting to build the medical community support Probuphine. We have also commence in a program to increase awareness of Probuphine in the medical community and we are seeing promising early outcomes. Ones still very early in the U.S. relaunch, that progress is now starting to be reflected in our financial results. When you look at a revenues on the sequential quarter-to-quarter basis product sales in the first quarter increased about 46% from the last quarter of 2018. The progress made by product development team and using grants to support future product pipeline is also very promising. And while grant revenues are important our primary focus remains on getting Probuphine related revenue to continue its growth trend. Outside of the U.S. we’re also looking forward to receiving the European commission's final decision on Sixmo. And to supporting our partner Molteni as it prepares for market launch in the world’s second largest market for buprenorphine-based products. This concludes our prepared remarks for today. Before I open the call to questions, I’d like to thank Titan’s Board Executive Management and staff for their continued hard work and dedication. So Keith we are ready to take questions from the call participants.

[Operator Instructions] And the first question comes from Ben Haynor with Alliance Global Partners.

Thanks for taking the questions and congrats on all the progress here and the development in Europe here recently.

Thank you, Ben.

Thanks Ben.

Good afternoon to you.

Thanks Ben. It’s excellent.

Yes. Thank you. So, first off, I guess, by the way like the name Sixmo, I think that’s pretty cleaver. But just curious on following the perspective clearance here at the end of June hopefully, how quickly might you guys be able to and your partners Molteni be able to get the first patient implanted in Europe or what’s kind of the time line there?

Sure. The process as you know, Ben, in Europe once the approval is received the company still needs to get the pricing approvals which happens for country-by-country based upon their local practices. That process is typically three, four-month process and that's what Molteni will be doing during that third quarter and early fourth quarter. So I expect certainly by the end of the year they will have started patient treatments in certain regions. They will not be going after all regions at the same time. So they have kind of selected clearly places where they feel they have the quickest and fastest way to get the product into the market and that’s what they have indicated they will be pursuing.

And then, obviously, congrats on setting up Accredo as well along with AllianceRx. Just curious on the integration with AppianRx and both of them; it sounds like its maybe in place with AllianceRx or not quite yet, I might have gotten confuse there. And how does that process work integrating the AppianRx and then the specialty pharmaceuticals?

Sure, Dane, can give you a good view on that.

So, Ben, good question. So I think lot of times patients services hubs, they remain kind of mystery to folks. And so, what this is, is really provide patient services and they process all of the prescriptions that physicians send in. And so Appian is now integrated. We got to integrated and fully functioning here in mid-April and it took some time and you have to build all the processes and SOPs and make sure we’re doing everything correctly and ensuring that the communications between the hub, the physicians and specialty pharmacies are functioning properly and so – and paperwork. So we -- for the most part have, automated the process, taken the heavy lift away from the physicians or the clinicians that are ordering Probuphine and automated that. So that the paperwork that’s done. It’s nearly online actually through our physician portal coming lives at the end of the month. But its all done and process at the hub and then do a benefits investigation which interacts with the specialty pharmacy. Now Walgreens is now integrated and shipping orders for us. So that, it started in mid-April. So, once we signed the agreement it took time for the ordering process and then the integration between our hub and Walgreens, so the communications in ordering process and shipping were flawless. We’re obviously we’re shipping a controlled substance to physicians offices and that has to be precise. So after several weeks of testing and ensuring that we’re doing that everything is functioning properly, we went live and so as you asked, Walgreens is now shipping and everything functioning as expected and its going very well.

And Accredo will take another several weeks or how long does that process take?

Yes. Accredo, it will take a couple of weeks to integrate the Accredo, but it shouldn't take too long. And I’m glad to have him on board. They are fantastic partner. We have orders already for Accredo waiting in queue. So we'll have them up and running here in a couple weeks.

Thanks for the explanation there. That’s very helpful. Then lastly from me and I’ll jump back in queue. Obviously the Justice Department has indicted one of all your larger competitor, have you seen any reaction either at the conferences that you been at or in the field to this? And then, I guess what do you think it might do to the industry as a whole? Does it maybe help you? Does it maybe hurt a little bit because there’s big sales force out there promoting buprenorphine as a treatment. How should we think about that?

I assume there's questions are for myself.

Whoever wants to take it I guess?

Let me try and address that for you, Ben. And I clearly, any disruption of that nature especially when you have the largest provider of buprenorphine products going through a legal process like this; it's never easy. It's not the best thing for the patients or the doctors or competitors. We don't directly compete with the daily dose products or even the monthly products that they were -- they continue to supply. So in essence for us it hasn't hindered us in any way. On the other hand obviously people ask questions like you do what do you think of it? And in my opinion they are still a major provider of products. They have a lot of boots on the ground and promote the use of buprenorphine all of which is very good and helpful for the whole industry. So I hope it gets resolved and things continue. I feel you know we are all providing a service for a patient population that truly needs it, and as many options and treatments that can be made available is very valuable. Marc or Dane, if anything else you know can add.

Yes. Ben, this Dane. One of the things when I came on and after discussing with leadership at Titan, Kate and Marc and Sunil; one of the things that was very important to the board and to our executive team is doing things right, always doing the right thing. And one way to always ensure that you don't make mistakes and you always do the right thing is to put in place a world class compliance program and we have that. And that was one of the very first things that we put in place. We have a compliance program. We have a Chief Compliance Officer. We have a board review of all materials, all activities, everything we do is scrutinized. And that's one of the reasons, the one of the aspects of the hub and certain things we do. It takes some time to get up to a launch readiness is that everything has to go through the regulatory compliance reviews and get approved and then submitted to OPDP, the FDA to show them exactly what we're doing. So always doing the right thing, ensuring we have processes and standard operating procedures in place to ensure that we're always training and ensuring that we're doing the absolute best we can do and the right thing with clinicians then for the patients because it's a tough market when you're out and you're doing your sales and you have to train on the exact verbiage and you do not deviate from the label and you can see what happens when I guess sales representatives and other folks possibly have allegedly deviated and we don't want that at Titan. We will not have that in Titan.

And the next question comes from Anita Dushyanth with Zacks Small-Cap Research.

I just have a couple here. Yes. Can you give me a sense of how the number of providers using Probuphine has changed over the last year? And also how the volume at each individual provider's practice has changed over time in the same period?

I can start and then Dane can add onto it as well. Last year when we took over Probuphine from Braeburn, in our conference calls we indicated, our initial focus was on physicians who were prescribing Probuphine at that time. And despite the fact that a large number had been trained by Braeburn, the real number of those prescribing was really small. It was less than a couple of hundred and we were starting to focus on really a 100 or so physicians who were actively prescribing the product at that time. So one of our goals was to make sure that our commercial read launch focuses on physicians who really have the right patient population, so that once they're trained they have the ability to start using the product quickly and that's very important. So that's what we’re focused on. And in a Kate’s team in training and Dane’s team in identifying the right physicians has been very effective in building that initial number as Dane mentioned up to close to 300 or so physicians right now. But that's sort of been the strategy around it. Dane, Kate, anything else.

Yes, absolutely. This is Dane. So as Sunil pointed out we had about 200 physicians that were writing the product. We're actually -- they like the product, they found patients were doing well. And one of the things that we encountered when we took the product back was the confidence factor. We had to reassure the patients, the clinicians, the caregivers that Probuphine was going to be supported by Titan. As you can imagine this requires a REMS training, it requires interaction excuse me with our MSL team, Kate's team. And when you're clinician you need to be reassured that if I have a question there's someone to talk to. And you know 80% of our time was spent really reassuring the marketplace that Titan was committed, committed to ensuring that the product remained on the market and that we were going to support it, and then once overcoming that initial hurdle was the retraining of some of the physicians and clinicians that had their certifications expired. So, we are now in a very good uptake phase where clinicians have now trust in Titan. They see their patients doing well and I expect things to continue in the upward trajectory for the next coming several months and this year. So I expect good things, positive results.

Absolutely. Thank you. That's helps a lot. And what are the next steps required between now and approval in the EU?

I think the question is what are the next steps required between now and approval. It's already under review at the EMEA for their final debate. There's nothing more for us to do at this point. Anita, we are -- now we've already gone through the process of responding to all of their questions. We had an oral hearing with them and answered questions in person. And at this point they are having their own internal meetings. And as I said earlier we expect to hear the final approval at the end of June.

And the last one will be you know on the previous calls you’ve highlighted the successes with the criminal justice system initiated and high prescribing physicians. How are the other parts of the marketing initiative progressing like maybe with academy institution?

We had an opportunity to meet with a number of leaders in the academic institutions at the recent ASAM meeting in Orlando and also at the Rx Drug Abuse & Heroin Summit. We also continue to meet regularly with NIDA leadership to give -- provide them with updates about our ongoing programs and how Probuphine is doing. So we're making those frequent connections and those relationships are as strong as they've ever been for us. We're also reaching out to training programs for nurse practitioners, physician assistants and to a lesser degree to addiction medicine physicians simply because those programs tend to be very small with only one or two fellows per academic site. We're really going for the places where there are larger numbers of clinicians that are qualified, that are eligible for training and who are very interested. This past year we did a preliminary training at Drexel University. We trained about 40 nurse practitioners who are graduating from Drexel this month in fact and we will be going back there to provide the final training and certification to those nurse practitioners who are licensed. This is a very important segment of our provider population that I described earlier. Does that answer your question?

Yes, yes, absolutely. Thank you. And thanks. That’s all from me and congrats on the process.

[Operator Instructions] And the next question comes from Deepankar Roy with Brookline Capital Markets.

Congrats on the progress and thanks for the updates and thanks for taking my question. I have a follow-up on the last question asked. I was actually curious about the training sessions at these summits and meetings that you guys are organizing. So specifically like what are these training sessions look like and who are you targeting. Are there like any doctor who wants to join can get trained or are you targeting high-prescribing doctors? And like what number of doctors do you plan to cover in these sessions in the coming months? And do you in reality expect to see any jump in the prescription numbers as the results of this training?

So, all great questions, Deepankar, I'm going to take the first few and then I'll probably ask Dane to address your very last question regarding do you expect to see an uptick in the number of doctors using the products. The way the training, the REMS training is designed, it's a three or four hour workshop, So there's a didactic portion where health care providers have a lecture and they learn about the product labeling. They learn about the indication. They learn about identifying the correct patients who are most likely to benefit from treatment. Then they learn in an academic lecture about how to do the procedures to insert Probuphine and remove Probuphine including proper aseptic wound care and teaching patients how to utilize proper aseptic wound care. Then they progressed to a practicum laboratory practicum in which they practice on a surgical meat model. They have to show that they can after they observe a demonstration by one of our master trainers then they have to demonstrate their own proficiency at inserting and removing Probuphine and they have to pass both a written and practicum examination in order to become certified and this is all part of our FDA mandated REMS program. It's something that a lot of health care providers are very interested doing as was mentioned during the call at the recent ASAM meeting we held a training on the last day of the meeting which was a Friday night, late Friday night and we literally had to turn people away. We didn't have enough room. And we certified 31 providers at that training. So we're getting a lot of uptick and interest in the training. Of course the procedure is reimbursed. So it's a nice thing for health care providers who want to do it. In terms of numbers of doctors, I really can't speak to that. I'm going to let Dane do it but just to finish with, we're looking for the right health care providers not necessarily a number or sheer volume of healthcare providers because we want these to be long term relationships. We want to make sure that these providers have the requisite expertise in either addiction medicine and or doing the surgery, they will have to have both perfect, but we want to have the right nurse practitioners, physician’s assistants and physicians who are going to partner with us over the long term.

Right. Absolutely. Dane, you want to add any comments on. I think Deepankar was asking about what do we expect in terms of prescriptions and growth in the business.

Right, right.

Yes.

Yes. Great question. And thanks Sunil. So yes, we we're seeing an uptick in prescriptions now. Now, the difference between the prescription and the shipment, so this is why we brought AppianRx in to automate this, to reduce and remove and eliminate the errors that take place, so think of it like a hub as a patient services call center and the physicians send in the patient information with a prescription. And this gets processed. So we'll see a number of prescriptions and we see that number increasing. And then you look at the number of shipments. Now we're reliant on the previous specialty pharmacy. The small ones we had in place that many times we’re out in that work with the payers. And so you saw more buying bill. And now that we have AllianceRx Walgreens and Accredo and hope you have another large one come on board. We'll have coverage where you won't see a lot of buy and bill prescriptions. And you'll see the speed to therapy of that patient journey. Once that prescription comes into our hub and goes to the specialty pharmacy after the benefits investigation they'll do a secondary benefits investigation with the payer to ensure coverage which we have really excellent coverage on the medical benefit side more than 92%. So we should start seeing a corresponding increase in the time from prescription to shipment. It's been delayed. Obviously it was you know it was going 60 90 days or greater. And that was clearly unacceptable for the providers of patients and for us. And we did not want to continue that because we couldn't continue in that fashion. So we've brought Appian. We've got solid specialty pharmacy partners and we've automated it and I expect to see not only the prescriptions increase but as well as the shipments and the time to speed to therapy increase. So like I said, we're starting to see that trend now and I expect that to increase positively over the course of the year.

I also want to ask about the second phase IV and the QT prolongation studies if you have any like expected timelines or outcomes that we should think about?

You know we haven't talked about those timelines yet. We are going to be initiating the studies, the first two certainly this year. I don't know an exact start date for the QT prolongation study. Again, that's kind first time ever industry consortium that the FDA has asked for amongst buprenorphine developers and marketers. So we're collaborating with our colleagues and I will be looking forward to giving you an update on that as you progress further.

All right. Thank you.

You’re welcome.

Thanks for the answers and congrats on the progress. Thanks.

Thank you.

Thanks Deepankar.

Thank you. And there are no more questions. I would like to turn the conference over Sunil Bhonsle for any closing comments.

Thank you. Thank you, Keith. Thank you everybody for participating in this call. As always, we appreciate the ongoing support and we look forward to reporting continued progress in our Probuphine commercial activities as well as our ProNeur portfolio as we move forward. So thank you and we'll speak to you again in a few months.

Thank you. The conference has now concluded. Thank you for attending today's presentation. You may now disconnect your lines.