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Kura Oncology and Kyowa Kirin Partner for Blood Cancer Therapy Development
Kura Oncology and Kyowa Kirin have announced a strategic collaboration to develop and commercialize ziftomenib, a promising therapy for acute myeloid leukemia, with significant financial and strategic implications.
Kura Oncology, Inc. and Kyowa Kirin Co., Ltd. have entered into a global strategic collaboration to develop and commercialize ziftomenib, a selective oral menin inhibitor, for the treatment of acute myeloid leukemia (AML) and other hematologic malignancies. This partnership marks a significant step in advancing precision medicine for cancer treatment. Under the terms of the agreement, Kura will receive a $330 million upfront payment and could earn up to $1.2 billion in milestone payments. The companies will share profits equally in the U.S., with Kura leading the development and commercialization efforts domestically, while Kyowa Kirin will handle these responsibilities internationally. Ziftomenib, which has received Breakthrough Therapy Designation from the FDA for R/R NPM1-mutant AML, is currently in early-stage development. The collaboration aims to expand its application to frontline treatments and combination therapies, with a New Drug Application expected in 2025. This partnership not only strengthens Kura's financial position but also leverages Kyowa Kirin's global expertise in hemato-oncology, potentially opening a $3 billion annual market opportunity in the U.S. alone. The collaboration is structured to support the ziftomenib program through commercialization, with shared governance and development costs starting in 2029. This strategic alliance underscores the potential of ziftomenib as a transformational therapy for AML patients worldwide.
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